每日大赛入口

Office:

BSB 4-109

Education and Training

• Universidad Austral de Chile, Valdivia, Chile
  1992, Licenciate in Biochemistry with distinction. (M.S. equivalent).
• 每日大赛入口. Brooklyn, NY
  2003, Doctor in Philosophy, State University of New York

Honors and Awards

• 1997-1998 Treasurer of the Graduate School Student Council at 每日大赛入口-HSCB.
• 2001 Research day Travel Fellowship award. School of Graduate Studies, 每日大赛入口-HSCB.
• 2003-2004 Ruth L. Kirchstein National Research Service Award. Training fellowship (T32)
• 2005-Dec 2006 Ruth L. Kirchstein National Research Service Award. Fellowship (T32).
• 2021 Annual Research Day. School of Graduate Studies, 每日大赛入口-HSCB
• 2024 Dominick J. DiMaio Research Scholar Award, The College of Medicine and School of Graduate Studies Annual Convocation & Awards Ceremony for the Class of 2024.

Committees, Council, and Professional Society Memberships

• 1998-Present, Society for Neuroscience
• 2003-Present, New York Academy of Science.

Laboratory Members / Personnel

• Gloria Patricia Baena-Caldas, DDM, MSc, PhD, Postdoctoral Associate. gloria.baenacaldas@downstate.edu
• Andrew Tcherepanov, PhD, Postdoctoral associate. Andrew.Tcherepanov@downstate.edu

Research or Clinical Interest Summary

Dr. Alejandro Iv谩n Hern谩ndez is an Assistant Professor in the Department of Pathology at 每日大赛入口. He is a biochemist and a graduate of the Universidad Austral de Chile. His thesis focused on the expression of vitellogenin and the hepatic 尾-estradiol receptor during the acclimatization of the fish Cyprinus carpio, conducted in the laboratory of Dr. Manuel Krauskopf under the supervision of Dr. Rodolfo Amthauer. His subsequent doctoral thesis, in the area of neuroscience, focused on the molecular basis of memory maintenance in the laboratory of Dr. Todd C. Sacktor at 每日大赛入口 Downstate Medical Center. His postdoctoral work focused on the study of chromatin remodeling in neuronal plasticity and memory, conducted in the laboratories of James H. Schwartz and Samuel Schacher at Columbia University. Currently, he is focused on studying the molecular basis of synaptic plasticity and long-term memory, as well as their relationship with neurodegenerative and developmental diseases such as Alzheimer's disease and Autism. His research explores how alterations in cellular machinery, such as ribosome biogenesis and energy synthesis, contribute to cognitive decline and other neuronal pathologies. His work suggests that altered ribosome and protein production are key cellular pathways affected in Alzheimer's disease. In more recent studies, he is also investigating the role of ribosome biogenesis in disorders such as autism spectrum disorder (ASD) and energy-related alterations in Alzheimer's disease. His team also conducts studies related to stroke and its treatment, such as evaluating the compound RNS60 for its ability to reduce early vasogenic edema, mitigate infarction, and protect motor and cognitive functions.

• Baena-Caldas Gloria P, Li Jie, Ghosh Supurna, Kalmes Andreas, Baird Alison, Barone Frank C, and A. Iv谩n Hern谩ndez. Abstract TP398: RNS60 Substantially Reduces Early Vasogenic Edema, Mitigates Infarct Area and Decreases Expression of HIF1伪 Four Days Post-Ischemic Stroke. Journal Stroke. 2025; 56(1). Available from: https://doi.org/10.1161/str.56.suppl_1.TP398
• Hou JY, Allen KD, Hernandez AI, Cottrell JE, Kass IS. Sevoflurane Preconditioning Rescues PKM味 Gene Expression from Broad Hypoxia-Induced mRNA Downregulation Correlating with Improved Neuronal Recovery. NeuroSci. 2025 Jan 28;6(1):9. doi: 10.3390/neurosci6010009
• Kaleck媒 K, Buitrago L, Alarcon JM, Singh A, Bottiglieri T, Kaddurah-Daouk R, Hern谩ndez AI; Alzheimer鈥檚 Disease Metabolomics Consortium. Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition. bioRxiv [Preprint]. 2025 Jan 18:2025.01.17.633452. doi:10.1101/2025.01.17.633452
• Vingan I, Phatarpekar S, Tung VSK, Hern谩ndez AI, Evgrafov OV, Alarcon JM. Spatially resolved transcriptomic signatures of hippocampal subregions and Arc-expressing ensembles in active place avoidance memory. Front Mol Neurosci. 2024 Oct 31;17:1386239. doi:10.3389/fnmol.2024.1386239
• Baena-Caldas GP, Li J, Pedraza L, Ghosh S, Kalmes A, Barone FC, Moreno H, Hern谩ndez AI. Neuroprotective effect of the RNS60 in a mouse model of transient focal cerebral ischemia. PLoS One. 2024 Jan 2;19(1):e0295504. doi: 10.1371/journal.pone.0295504. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295504
• Sokas P, Hsieh C, Flores-Obando RE, Bernabo M, Tcherepanov A, Hern谩ndez AI, Thomas C, Bergold PJ, Cottrell JE, Kremerskothen J, Shouval HZ, Nader K, Fenton AA, Sacktor TC. KIBRA anchoring the action of PKM味 maintains the persistence of memory. Sci Adv. 2024 Jun 28;10(26):eadl0030. doi: 10.1126/sciadv.adl0030
• Baena-Caldas Gloria P, Li Jie, Ghosh Supurna, Kalmes Andreas, Barone Frank C, Moreno Herman and A. Iv谩n Hern谩ndez. Abstract TP219: RNS60 brain protection in mouse ischemic stroke mitigates plasma tau and cortical microvascular perfusion. Journal Stroke. 2023; 54(1). Available from: https://www.ahajournals.org/doi/10.1161/str.54.suppl_1.TP219
• Baena-Caldas Gloria P, Li Jie, Pedraza Ortiz Lina Marcela, Ghosh Supurna, Kalmes Andreas, Barone Frank C, Moreno Herman and Hern谩ndez Alejandro. Abstract WP257: RNS60 provides acute and chronic protection of brain cells and function in a mouse stroke model. Journal Stroke. 2022; 53(1). Available from: https://doi.org/10.1161/str.53.suppl_1.WP257
• Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer鈥檚 Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hern谩ndez AI, Kastenm眉ller G, Baillie R, Han X, Kaddurah-Daouk R. Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6
• Flores-Obando RE, Freidin MM, Hern谩ndez AI, Abrams CK. Activation of the unfolded protein response by Connexin47 mutations associated with Pelizaeus-Merzbacher-like disease. Mol Cell Neurosci. 2022 May;120:103716. doi: 10.1016/j.mcn.2022.103716. Epub 2022 Mar 8. PMID: 35276347.
• Hsieh C, Tsokas P, Grau-Perales A, Lesburgu猫res E, Bukai J, Khanna K, Chorny J, Chung A, Jou C, Burghardt NS, Denny CA, Flores-Obando RE, Hartley BR, Rodr铆guez Valencia LM, Hern谩ndez AI, Bergold PJ, Cottrell JE, Alarcon JM, Fenton AA, Sacktor TC. Persistent increases of PKM味 in memory-activated neurons trace LTP maintenance during spatial long-term memory storage. Eur J Neurosci. 2021 Oct;54(8):6795-6814. PMID: 33540466
• Laing KK, Simoes S, Baena-Caldas GP, Lao PJ, Kothiya M, Igwe KC, Chesebro AG, Houck AL, Pedraza L, Hern谩ndez AI, Li J, Zimmerman ME, Luchsinger JA, Barone FC, Moreno H, Brickman AM; Alzheimer鈥檚 Disease Neuroimaging Initiative. Cerebrovascular disease promotes tau pathology in Alzheimer's disease. Brain Commun. 2020 Aug 19;2(2):fcaa132. doi: 10.1093/braincomms/fcaa132. PMID: 33215083; PMCID: PMC7660042.
• Regier M, Liang J, Choi A, Verma K, Libien J, Hern谩ndez AI. Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural Plast. 2019 Nov 19;2019:4383258. doi: 10.1155/2019/4383258. PMID: 31827497; PMCID: PMC6885846.
• Allen KD, Regier MJ, Hsieh C, Tsokas P, Barnard M, Phatarpekar S, Wolk J, Sacktor TC, Fenton AA, Hern谩ndez AI. Learning-induced ribosomal RNA is required for memory consolidation in mice-Evidence of differentially expressed rRNA variants in learning and memory. PLoS One. 2018 Oct 3;13(10):e0203374. doi: 10.1371/journal.pone.0203374. Erratum in: PLoS One. 2018 Nov 5;13(11):e0207142. PMID: 30281601; PMCID: PMC6169870.
• Arora K, Sequeira JM, Hern谩ndez AI, Alarcon JM, Quadros EV.( 2017)  Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse. PLoS One. 2017 May 18;12(5):e0177156. doi:10.1371/journal.pone.0177156.
• Hsieh C, Tsokas P, Serrano P, Hern谩ndez AI, Tian D, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. Persistent increased PKM味 in long-term and remote spatial memory. Neurobiol Learn Mem. 2017 Feb;138:135-144. doi: 10.1016/j.nlm.2016.07.008. Epub 2016 Jul 11. PMID: 27417578; PMCID: PMC5501180.
• Tsokas P, Hsieh C, Yao Y, Lesburgu猫res E, Wallace EGC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hern谩ndez AI, Cottrell J, Shouval HZ, Fenton AA, Sacktor TC (2016). Compensation for PKM味 in LTP and spatial long-term memory in mutant mice. Elife. 2016 May 17;5. pii: e14846. doi: 10.7554/eLife.14846.
• Zeng J, Libien J, Shaik F, Wolk J, Hern谩ndez AI. Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. Neural Plast. 2016;2016:8987928. doi: 10.1155/2016/8987928. Epub 2016 Feb 29. PMID: 27034851; PMCID: PMC4789469.
• Hern谩ndez AI, Alarcon J.M., Allen K.D. (2015). 鈥淣ew Ribosomes for new memories?鈥� Commun & Integr Biol. 8, e1017163.
• Allen K.D., Gourov A.V., Harte C., Gao P., Lee C., Sylvain D., Splett J.M., Oxberry W.C., van de Nes P.S., Troy-Regier M.J., Wolk J., Alarcon J.M., Hern谩ndez AI (2014). Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. PLoS One 9:e104364.
• Hern谩ndez A.I., Oxberry W.C., Crary J.F, Mirra S.S., Sacktor T.C. (2013). Cellular and subcellular localization of PKM味. Philos Trans R Soc Lond B Biol Sci 369:20130140.
• Hern谩ndez A.I., Wolk J., Hu J.Y., Liu J., Kurosu T., Schwartz J.H., Schacher S. (2009). Poly-(ADP-ribose) Polymerase-1 is Necessary for Long-Term Facilitation in Aplysia. J. Neurosci. 29:9553-9562.
• Moreno, H., Yu, E., Pigino, G., Hern谩ndez, A.I., Kim, N., Moreira, J., Sugimori, M., Llinas RR (2009). Synaptic transmission block by pre-synaptic injection of oligomeric amyloid beta. Proc Natl Acad Sci U S A. 106(14):5901-6.
• Kurosu T., Hern谩ndez A.I., Wolk J., Liu J.,Schwartz JH. (2009). 伪/尾-tubulin are A kinase Anchor Proteins for Type I PKA in Neurons. Brain Res 1251:53-64.
• Kurosu T, Hern谩ndez AI, Schwartz JH. (2007). Serotonin induces selective cleavage of the PKA RI but not RII subunit in Aplysia neurons. Biochem. Biophys. Res. Commun. 359 (2007):563鈥�567.
• Crary, J.F., Mirra, S.S., Shao, C.Y., Sheffield, L.G., Mirra, S.S., Hern谩ndez, A.I., Sacktor, T.C. (2006). Atypical Protein Kinase C in Neurodegenerative Disease I: PKM味 aggregates with limbic neurofibrillary tangles and AMPA receptors in Alzheimer鈥檚 disease. J. Neuropathol. Exp. Neurol. 265(4):319-326.
• Muslimov I.A., Nimmrich V., Hern谩ndez A.I., Tcherepanov A., Sacktor T.C., Tiedge H. (2004). Dendritic transport and localization of protein kinase M味 mRNA: implications for molecular memory consolidation. J. Biol. Chem. 279(50):52613-22.
• Hern谩ndez, A.I., Blace, N., Crary, J.F., Serrano, P.A., Leitges, M., Libien, J.M., Weinstein, G., Tcherapanov, A., and Sacktor, T.C. (2003). PKM味 synthesis from a brain mRNA encoding an independent PKC味 catalytic domain: implications for the molecular mechanism of memory. J. Biol. Chem. 278 (41):40305-40316.
• Polesskaya, O.O., Haroutunian. V., Davis, K.L., Hern谩ndez I., Sokolov, B.P. (2003). Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia. J. Neurosci. Res. 74(1):111-22.
• Naik, M.U., Benedikz, E., Hern谩ndez, I., Libien, J., Hrave, J., Valsamis, M., Dow-Edwards, D., Osman, M., and Sacktor, T.C., (2000). Expression of Protein Kinase M味 and the Complete Protein Kinase C isoform Family in Rat Brain. J. Comp. Neuro. 426(2):243-258.
• Hern谩ndez, I. and Sokolov, B.P. (2000). Abnormalities in 5-HT2A receptor mRNA expression in Frontal Cortex of Chronic Elderly schizophrenics with varying histories of neuroleptic treatment. J. Neurosci. Res. 59:218-225.
• Hern谩ndez, I. and Sokolov, B.P. (1997). Abnormal Expression of Serotonin Transporter mRNA in the Frontal and Temporal Cortex in Schizophrenia. Molec. Psych. 2: 57-64.
• Hern谩ndez, I., Poblete, A., Amthauer, R., Pessot, R., and Krauskopf, M. (1992). Effect of seasonal acclimatization on estrogen induced vitellogenesis and on the hepatic estrogen receptor in the male carp. Biochem. Int. 28:557-559.