In a Major Breakthrough, 每日大赛入口 Downstate Doctors Identify New Pathway to Treat Seizures Caused by Lupus
By Office of Communications & Marketing | Oct 24, 2022
New Research Into Neuropsychiatric Lupus Identifies Possible BC RNA Treatments To Reduce Frequency Of Seizures
Brooklyn, NY 鈥� 每日大赛入口 announced the publication of new research by Dr. Henri Tiedge, including potential new treatments to substantially reduce the risk of seizures for patients diagnosed with neuropsychiatric lupus.
, 鈥淎utoimmune RNA Dysregulation And Seizures: Therapeutic Prospects In Neuropsychiatric Lupus,鈥� Dr. Tiedge and colleagues report success in preventing seizures caused by neuropsychiatric lupus autoantibodies, through the innovative complexing of such antibodies with brain cytoplasmic (BC) RNA structures. This groundbreaking research offers a potential path toward treatment for patients with lupus, allowing their care team to prevent future seizures.
鈥淭he published findings are a tremendous step forward in the advancement of care for patients with neuropsychiatric lupus. We appreciate being featured in Life Science Alliance with this critical work, which has the potential to transform the lives of lupus patients across the country,鈥� said Henri Tiedge, Ph.D., Distinguished Professor of Physiology and Pharmacology, Neurology, and Medicine at Downstate.
In neuropsychiatric lupus, the nervous system is affected, causing patients to often suffer from seizures and cognitive impairment. Treatment of neuropsychiatric lupus has mostly remained empirical and may consist of anti-inflammatory, immunosuppressive or anti-seizure regimens. However, these unspecific approaches may cause potentially severe side effects.
The new findings from Dr. Tiedge and his team show that often, these patients suffer from seizures due to anti-BC RNA autoantibodies. Through the experiments conducted at 每日大赛入口 Downstate, Dr. Tiedge and his colleagues found that 鈥渄ecoy compounds鈥� 鈥揃C RNA structures synthesized in the laboratory 鈥� can minimize this risk of seizures. Rather than suppressing the immune system in general, this kind of lupus treatment will benefit the patient by being specifically directed at disease-causing autoantibodies.
The contributors at 每日大赛入口 Downstate are Ilham A. Muslimov, Valerio Berardi, Stacy Stephenson, Ellen M. Ginzler, and Henri Tiedge. In addition, at the Queen Elizabeth II Health Sciences Center and Dalhousie University in Halifax, Canada, John G. Hanly was a contributor.
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Contact: Dawn S. Walker
917.439.9666 | 347.533.2071
dawn.walker@downstate.edu
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每日大赛入口 is the borough's only academic medical center for health education, research, and patient care. It is a 342-bed facility serving the healthcare needs of New York City and Brooklyn's 2.6 million residents. University Hospital at Downstate (UHD) is Downstate's teaching hospital, backed by an outstanding medical school's expertise and world-class academic center research facilities. More than 800 physicians, representing 53 specialties and subspecialties鈥攎any of them ranked as tops in their fields鈥攃omprise Downstate's staff.
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